Product Name :
2-Methylthio-N6-threonylcarbamoyladenosine (CAS 70333-82-3)
Synonym :
N-[[[2-(Methylthio)-9-β-D-ribofuranosyl-9H-purin-6-yl]amino]carbonyl]-L-threonine
Application :
CAS:
70333-82-3
Purity:
≥98%
Molecular Weight:
458.45
Formula :
C16H22N6O8S
Physical state:
Liquid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
References:
:Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU species. | Yarian, C., et al. 2000. Biochemistry. 39: 13390-5. PMID: 11063576Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A. | Stuart, JW., et al. 2000. Biochemistry. 39: 13396-404. PMID: 11063577Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications.114932-60-4 uses | Agris, PF. 2008. EMBO Rep. 9: 629-35. PMID: 18552770Identification of urinary modified nucleosides and ribosylated metabolites in humans via combined ESI-FTICR MS and ESI-IT MS analysis. | Bullinger, D., et al. 2008. J Am Soc Mass Spectrom. 19: 1500-13. PMID: 18657436Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. | Arragain, S., et al. 2010. J Biol Chem. 285: 28425-33. PMID: 20584901Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human. | Zhou, B., et al. 2014. Hum Mol Genet. 23: 4639-50. PMID: 24760768Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA. | Thiaville, PC., et al. 2014. RNA Biol. 11: 1529-39. PMID: 25629598Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. | Gao, BZ., et al. 2015. Evid Based Complement Alternat Med.(R)-SITCP Price 2015: 501272. PMID: 26504476Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.PMID:33742256 | Takahashi, N., et al. 2017. Nucleic Acids Res. 45: 435-445. PMID: 27568003Chemical Synthesis of Oligoribonucleotide (ASL of tRNALys T.brucei) Containing a Recently Discovered Cyclic Form of 2-Methylthio-N6 -threonylcarbamoyladenosine (ms2 ct6 A). | Debiec, K., et al. 2019. Chemistry. 25: 13309-13317. PMID: 31328310Biosynthesis and Degradation of Sulfur Modifications in tRNAs. | Shigi, N. 2021. Int J Mol Sci. 22: PMID: 34769366New Efficient Synthesis of tRNA Related Adenosines Bearing the Hydantoin Ring (ct6 A, ms2 ct6 A) by Intramolecular Cyclization of N6 -(N-Boc- alpha -aminoacyl)-adenosine Derivatives. | Frankowska, K. and Sochacka, E. 2022. Chembiochem. 23: e202100655. PMID: 34997683Abundances of transfer RNA modifications and transcriptional levels of tRNA-modifying enzymes are sex-associated in mosquitoes. | Kelley, M., et al. 2022. Insect Biochem Mol Biol. 143: 103741. PMID: 35181477