Product Name :
3-Cysteinylacetaminophen trifluoroacetic acid salt (CAS 1331891-93-0)
Synonym :
S[5-(Acetylamino)-2-hydroxyphenyl]-L-cysteine Trifluoroacetic Acid Salt; APAP-CYS trifluoroacetic acid salt
Application :
3-Cysteinylacetaminophen trifluoroacetic acid salt is an acetaminophen metabolite
CAS:
1331891-93-0
Purity:
≥95%
Molecular Weight:
384.33
Formula :
C11H14N2O4S•C2HF3O2
Physical state:
Solid
solubility :
Soluble in DMSO, and methanol.
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
CC(=O)NC1=CC(=C(C=C1)O)SC[C@@H](C(=O)O)N.C(=O)(C(F)(F)F)O
References:
:Simultaneous quantification of acetaminophen and structurally related compounds in human serum and plasma. | Bylda, C., et al. 2014. Drug Test Anal. 6: 451-60. PMID: 24000098Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum. | Bylda, C., et al. 2015. Drug Test Anal. 7: 457-66. PMID: 25231125Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: clinical and animal model applications. | Cook, SF., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 985: 131-41. PMID: 25681644Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. | Xie, Y., et al. 2015. Xenobiotica. 45: 921-9. PMID: 25869248Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study. | Cook, SF., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1007: 30-42. PMID: 26571452Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain. | Muramatsu, S., et al. 2016. Anesth Pain Med.93-35-6 site 6: e32873.36805-97-7 MDL No. PMID: 27110534Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.PMID:33417502 | McGreal, SR., et al. 2018. Toxicol Sci. 162: 599-610. PMID: 29325178A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition. | Wang, YX., et al. 2019. Chin J Nat Med. 17: 517-524. PMID: 31514983The Impact of Proximal Roux-en-Y Gastric Bypass Surgery on Acetaminophen Absorption and Metabolism. | Chen, KF., et al. 2020. Pharmacotherapy. 40: 191-203. PMID: 31960977Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates. | Koenderink, JB., et al. 2020. Arch Toxicol. 94: 3027-3032. PMID: 32472168The use of alkoxycarbonyl derivatives for the mass spectral analysis of drug-thioether metabolites. Studies with the cysteine, mercapturic acid and glutathione conjugates of acetaminophen. | Hoffmann, KJ. and Baillie, TA. 1988. Biomed Environ Mass Spectrom. 15: 637-47. PMID: 3416089Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme. | Yang, W., et al. 2022. Molecules. 27: PMID: 36557984Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses. | Rogers, LK., et al. 1997. Chem Res Toxicol. 10: 470-6. PMID: 9114986