Product Name :
3-Hydroxyglutaric Acid (CAS 638-18-6)
Synonym :
3-Hydroxyglutaric Acid is also known as 3-HG.
Application :
3-Hydroxyglutaric Acid is a glutaric acid derivative and byproduct of Glutaric acidemia type I, used as a marker for GCDH deficiency.
CAS:
638-18-6
Purity:
Molecular Weight:
148.11
Formula :
C5H8O5
Physical state:
Solid
solubility :
Solubility: Soluble in Methanol and Water
Shipping Condition :
Store at -20° C
Melting point:
94-96° C
SMILES:
C(C(CC(=O)O)O)C(=O)O
References:
:3-Hydroxyglutaric and glutaric acids are neurotoxic through NMDA receptors in vitro. | Kölker, S., et al. 1999. J Inherit Metab Dis. 22: 259-62. PMID: 10384382Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. | Kölker, S., et al. 2000. Pediatr Res. 47: 495-503. PMID: 10759157IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures. | Bjugstad, KB., et al. 2001. J Inherit Metab Dis. 24: 631-47. PMID: 117685833-Hydroxyglutarate excretion is increased in ketotic patients: implications for glutaryl-CoA dehydrogenase deficiency testing. | Pitt, J., et al. 2002. J Inherit Metab Dis. 25: 83-8. PMID: 12118531Quantification of 3-hydroxyglutaric acid in urine, plasma, cerebrospinal fluid and amniotic fluid by stable-isotope dilution negative chemical ionization gas chromatography-mass spectrometry. | Schor, DS., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 780: 199-204. PMID: 123834963-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats. | Frizzo, ME., et al. 2004. Neurochem Int. 44: 345-53. PMID: 146437523-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells. | Freudenberg, F., et al. 2004. Neurobiol Dis. 16: 581-4. PMID: 15262270Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats.696-63-9 Molecular Weight | Rosa, RB.71432-55-8 web , et al.PMID:33539848 2004. Neurochem Int. 45: 1087-94. PMID: 15337308Promotion of oxidative stress by 3-hydroxyglutaric acid in rat striatum. | Latini, A., et al. 2005. J Inherit Metab Dis. 28: 57-67. PMID: 157024063-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3. | Stellmer, F., et al. 2007. J Mol Med (Berl). 85: 763-70. PMID: 17356845Evidence for a synergistic action of glutaric and 3-hydroxyglutaric acids disturbing rat brain energy metabolism. | Ferreira, GC., et al. 2007. Int J Dev Neurosci. 25: 391-8. PMID: 17643899Quantitation of plasma and urine 3-hydroxyglutaric acid, after separation from 2-hydroxyglutaric acid and other compounds of similar ion transition, by liquid chromatography-tandem mass spectrometry for the confirmation of glutaric aciduria type 1. | Simon, GA. and Wierenga, A. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1097-1098: 101-110. PMID: 30218917Formation of 3-hydroxyglutaric acid in glutaric aciduria type I: in vitro participation of medium chain acyl-CoA dehydrogenase. | Peters, V., et al. 2019. JIMD Rep. 47: 30-34. PMID: 31240164