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The forkhead transcription issue household is characterized by a winged-helix DNA binding motif as well as the forkhead domain [1]. The mammalian forkhead transcription factors of your O class (FOXOs) have 4 members: FOXO1, FOXO3, FOXO4, and FOXO6. FOXO1 and FOXO3 are expressed in almost all tissues. FOXO4 is highly expressed in muscle, kidney, and colorectal tissue when FOXO6 is mainly expressed in the brain and liver [2]. More than the last decade, research have demonstrated that FOXOs play critical roles in a wide number of cellular processes. FOXOs transcriptionally activate or inhibit dow.
