Product Name :
SPATA13 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
APC-stimulated guanine nucleotide exchange factor 2 antibody ARHGEF29 antibody Asef2 antibody FLJ31208 antibody RP11-307N16.3 antibody Spata13 antibody Spermatogenesis-associated protein 13 antibody SPT13_HUMAN antibody
Function :
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within Human SPATA13 aa 423-572 / 652.
Species reactivity:
Human, Rat, Mouse
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069417
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1000575-20-1 uses Aliquot store at -20℃.Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical name Avoid repeated freeze / thaw cycles.PMID:33687435
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 75 kDa
Positive control :
Rat kidney tissue lysates, rat testis tissue, human colon cancer tissue, human kidney tissue, SHSY5Y.