Product Name :
SARM1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
FLJ36296 antibody KIAA0524 antibody MyD88-5 antibody SAM and ARM-containing protein antibody SAM domain-containing protein 2 antibody SAMD2 antibody SARM 1 antibody SARM1 antibody SARM1_HUMAN antibody Sterile alpha and Armadillo repeat protein antibody 展开
Function :
caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method. Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. Contains 1 TIR domain. Contains 2 SAM (sterile alpha motif) domains. subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthesized peptide derived from human protein . at AA range: 281-330
Species reactivity:
Human, Mouse
Verify application:
WB
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Buytert-Butyl 5-aminopentanoate Aliquot store at -20℃ or -80℃.Price of 1500974-00-4 Avoid repeated freeze / thaw cycles.PMID:33691307
Storage buffer solution:
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
79 kDa
Positive control :
Brain,PCR rescued clones,